Howey is perhaps best known starring as
Georgia Miller in the
Netflix series
Ginny & Georgia. and quickly became popular, attracting 52 million viewers on Netflix. It was renewed for a second season on April 19, 2021. After the Season 2 release, Ginny & Georgia was the most-watched title from January to June 2023 on Netflix, with a combined 967.2M hours viewed between Seasons 1 and 2. In May 2023, the series was renewed for a third and fourth season. The third season was released on June 5, 2025. Her first television role was on
90210, when she played Stacey while continuing at NYU. She also starred in
Twisted Tales in 2013. In 2015, Howey moved to London to film her first series regular starring role which was in the Comedy Central UK television series
I Live with Models, which aired for two seasons. During that time, Brianne recurred in the Fox series
Scream Queens and the Showtime series ''
I'm Dying Up Here''. In 2016, Howey landed the role of Kat Rance in the television series
The Exorcist, as the sister of the possessed girl played by
Hannah Kasulka, with
Geena Davis and
Alan Ruck playing their parents. In 2019, Howey starred as Shauna Babcock, a "Viral", in
Justin Cronin's
The Passage. The same year, Howey began a recurring role as Alison B. in
Hulu's
Dollface. She returned for season 2 in February 2022. She also had a role in the 2019 romantic comedy
Plus One. In 2024, she starred as “Molly Turner” in the Farrelly brothers holiday comedy
Dear Santa. In 2025, she starred in Happy Madison Netflix film
Kinda Pregnant. == Personal life ==