Discoveries in Serra del Monte indicate the area was frequented in the
Neolithic period. After the
Lombard period, the municipal territory of Brignano-Frascata was under the control of
Bobbio Abbey, which added it to the monastic court of
Casasco. Later, during the
High Middle Ages, the area was under the jurisdiction of the
bishops of Tortona from 1157. In 1375, it became a
fief of the
Duke of Milan, granted to the
Genoese Spinola family. On the morning of June 1, 1478, Napoleone and Giovanni Antonio Spinola attacked their brother Battista and his family in the castle of Brignano. Battista and his three sons were killed in the attack, and one of his daughters died shortly after from her injuries. As a result of the confiscation of the assassins' assets, the fief passed to Battista's son-in-law Enrico Bigurra, who sold it in 1485 to Cavalchino Guidobono for 13,500 imperial
lira. From 1685 to around 1800 the area belonged to the Ferrari of San Sebastiano. It became a
comune in 1928 following the merger of the
comuni of Brignano del Curone and Frascata. Until 1947, the
comune also included the territory of the
comune of
Momperone. ==References==