WNBA Atlanta Dream After being drafted to the Atlanta Dream with the seventh pick of the 2017 WNBA draft, Sykes completed a very successful rookie year. She signed a three-year deal that started with a base salary of $47,738 in the first year, jumps to $48,693 in the second, $53,563 in the third and $60,867 in a fourth-year option (typical rookie contract). She was named to the 2017 WNBA all rookie team. She averaged 13.9 points per game (with a career high of 33 points against the
Phoenix Mercury) and her 471 points was a new single-season rookie record for the
Atlanta Dream franchise.
Los Angeles Sparks In February 2020, Sykes was traded to the
Los Angeles Sparks, along with center
Marie Gülich in exchange for center
Kalani Brown. In 2021 she earned WNBA All-Defensive First Team honors and was second in voting for Defensive Player of the Year. She played for the Sparks for three years.
Washington Mystics In February 2023, Sykes was traded to the
Washington Mystics. During her 2 1/2 seasons with Washington, she earned WNBA All-Defensive First Team honors, her first All-Star selection, and averaged 15.0 points, 4.3 rebounds, and 3.8 assists per game.
Seattle Storm On August 5, 2025, Sykes was traded to the
Seattle Storm in exchange for forward
Alysha Clark, guard
Zia Cooke, and Seattle's first-round pick in the 2026 WNBA Draft.
Toronto Tempo On April 10, 2026, Sykes signed a two-year max contract with the
Toronto Tempo for their inaugural season.
Overseas Sykes played for Hapoel Petah Tikva in the
Israeli Female Basketball Premier League in 2017. From that time on she regularly played in other overseas leagues during the WNBA offseason. These included in Turkey (
OGM Ormanspor, 2018 and 2020–21; and
Çukurova Basketbol, 2020), Spain (
Uni Girona CB, 2019, 2022–23), Australia (
University of Canberra Capitals, 2021–22), Hungary (
Sopron Basket, 2022), and Poland (
CCC Polkowice, 2023–24).
Unrivaled On September 23, 2024, it was announced that Sykes would appear and play in the inaugural season of
Unrivaled, the women's 3-on-3 basketball league founded by
Napheesa Collier and
Breanna Stewart. She was selected for
Rose BC. Her team,
Rose BC, won the first ever
Unrivaled League Championship, in a game where she sank the winning shot and led the team in scoring. On November 5, 2025, it was announced that Sykes had been drafted by
Laces BC for the
2026 season. ==National team career==