BRPF1, which is coordinated by its particular set of PWWP domains, mediates
Moz -dependent histone acetylation and maintains
Hox genes expression throughout vertebrate development, hence determines the proper pharyngeal segmental identities. Furthermore,
Brpf1 may not only has significant role for maintaining the anterior-posterior axis of the craniofacial skeleton, but also the dorsal-ventral axis of the caudal skeleton. Recent studies have shown that ablation of the mouse
Brpf1 gene causes embryonic lethality at embryonic day 9.5.
Brpf1 shares
phenotypes with
transcription factors
Sox2,
Tlx and
Tbr2 in
dentate gyrus development and has potential link to
neural stem cells and
progenitors.
Cancer development Recently,
Brpf1 was reported to play the
tumor suppressor or oncogenic role in several malignant tumors, including
leukemia,
medulloblastoma and
endometrial stromal sarcoma.
Brpf1 was considered a tumor suppressor gene because mutations in cancer cells appear to diminish the function of
Brpf1 However, oncogenic role of
Brpf1 is also possible in cancer. For example,
Brpf1 can form a stable complex with
Moz-Tif2, which could lead to the development of human
acute myeloid leukemia (
AML). There is another
Brpf1 related complex
Brpf1–Ing5–Eaf6, which also plays a direct role in cancer. ==See also==