From 2015, Lowe appeared in a recurring role in comedy series
The Grinder. In 2017, he appeared on
The Lowe Files, in which his family explored unsolved mysteries. He appeared in the Christmas film
Holiday in the Wild in 2019, and worked as a writer on multiple episodes of
9-1-1: Lone Star. In March 2023, Lowe began starring in the
Netflix comedy series
Unstable, which he also executive produced alongside his father and
Victor Fresco. The series was inspired by Lowe's relationship with his father. He also featured in the second season which was released in August 2024. Lowe was actor and producer on psychological thriller film
Grace Point, released in January 2025, co-starring
Andrew McCarthy and directed and co-written by
Rory Karpf.{{cite web|url= https://deadline.com/2024/10/andrew-mccarthy-john-owen-lowe-grace-point-entertainment-squad-american-film-market-1236163457/|website=Deadline Hollywood|accessdate=23 Dec 2025|title= Andrew McCarthy & John Owen Lowe Thriller ‘Grace Point’ Lands U.S. Release — AFM ==Personal life==