Buhweju District is bordered by
Rubirizi District to the west and northwest,
Ibanda District to the northeast,
Mbarara District to the east,
Sheema District to the southeast, and
Bushenyi District to the southwest.
Nsiika, the location of the district headquarters, is approximately northwest of
Mbarara, the largest city in
Ankole sub-region. This location is approximately , by road, southwest of
Kampala, the capital of
Uganda and the largest city in that country. The coordinates of the district are:00°20'40.0"S, 30°25'00.0"E (Latitude:-0.344444; Longitude:30.416667). Due to the marked scarp that follow its southern, eastern and much of the northern boundaries, Buhweju is considered to be the most isolated county in Ankole. ==Overview==