Following his study in Madras Medical College, he completed
DPH, DTMH and DB from
University of Cambridge and
University of London. He worked for a short period as the Medical Officer of an estate and then as the Health Officer of Thiruvananthapuram. Later he took over as the Superintendent of Public Health Laboratory near Civil Hospital (present Trivandrum General Hospital) at Thiruvananthapuram.
Sir C.P. Ramaswamy Aiyer realising his abilities, sent him to United States of America for industrial training. When he returned he improvised the laboratory and in 1948, he was appointed as the Special Officer for establishing the first medical college in the state of Travancore-Cochin at Trivandrum. With his effort the plans for construction of the
Government Medical College, Thiruvananthapuram was finalised in a year and construction of the college completed in just 16 months. He was appointed as the first principal of Government Medical College, Thiruvananthapuram and Professor of Microbiology. Realizing his dream for getting maximum international exposure to the students of the college, World Health Organization at his request sent the then DHS of Sweden,
Dr. Axel J. Hojer as an expert. Dr. C.O. Karunakaran then stepped down as Principal and gave the Principalship to Dr. Hojer and continued as Vice Principal under him.. He was also instrumental in bringing many international experts including Dr.
Alexander Fleming to the college. He has also served as a member and Dean of Senate and Syndicate of the
University of Kerala. He had been the Chairman of Travancore Medical Council and President of
Indian Medical Association from 1958 to 1959. He was awarded the RajyaSevaNirata award by
Sri Chithira Tirunal considering his contributions to the country. The first voicing for family planning in India was by Dr. C.O. Karunakaran in his famous Karthikapally speech in 1925. In 1957 he himself was behind the family planning drive started in Kerala and was the chief adviser of State Family Planning Board and Family Planning Communication Research project. He died on 30 November 1970. In his will he had stated that no state honours or religious rituals be performed at his funeral. It also had stated that the body should not be kept for more than six hours. == Family ==