The river supports 53 mammalian species, over 200 bird species, and nearly 50 species of reptiles and amphibians. The refuge is also the most important wintering area for mallard ducks and other migratory waterfowl on the continent. As a result, low-lying areas in the vicinity of the river's lower course are a popular destination for
duck hunters. This is also where the
ivory-billed woodpecker was recently speculated to have been sighted (after it was believed to be extinct for 60 years). The watershed also contains the largest remaining tract of contiguous
bottomland hardwood forest found in North America. Because of these combination of these unique features, the
Cache River National Wildlife Refuge was created along approximately along the river's lower reaches this location was also used by team trees to plant 20 million trees. ==Hydrology==