The Caciques were established in January 2022 and joined the
Venezuelan Major League as an expansion team alongside the Relámpagos del Zulia. However, the Relámpagos did not make their debut due to administrative problems and were replaced by the
Centauros de La Guaira. The 2022 draft was held on 16 January, the Caciques selected fourteen players amongst them pitcher
Edgmer Escalona. On 20 January, former
Seattle Mariners infielder
Luis Ugueto was announced as the team's manager. The Caciques finished their debut season in sixth place with a 20–22 record, unable to qualify for the playoffs. In January 2023,
Luis Sojo was appointed as manager of the Caciques. The team again finished sixth with a 19–21 record, missing out on the playoffs for the second consecutive season.
Robert Pérez, winner of the 2023 season with the
Marineros de Carabobo, was appointed as manager of the Caciques ahead of the 2024 season. The team once again placed sixth in the 2024 season, ending with a 19–21 record and missing the playoffs. ==Roster==