Cannabidiolic acid synthase
catalyses the production of
cannabidiolate predominantly from
cannabigerolate by stereospecific oxidative cyclization of the
geranyl group of
cannabigerolic acid according to the following
chemical reaction: :
cannabigerolate + O2 →
cannabidiolate + H2O2
Cannabinerolate can also be used as a substrate, but with lower efficiency (
KM=0.137 mM) than
cannabigerolate (KM=0.206 mM). It
covalently binds FAD, and does require coenzymes & molecular oxygen for the oxidocyclization reaction. The optimum pH for CBDA synthase is 5.0. == References ==