The church originally built at this location in the mid-17th century was a mud-walled chapel and dedicated to St. James (Santiago). It was destroyed during the earthquake of 1641. The building has undergone rebuilding, restoration, or expansion on numerous occasions since. The first construction of the cathedral replacing the small church commenced in 1666 under
Juan de Medina, and a bell tower was added. Construction was completed in 1674. The façade, dating from 1771, is the work of
Francisco Andrés de Meneses. The building was again damaged in the earthquakes of 1766 and 1812. After the earthquake, one of its towers was damaged and later reduced in size. A frontispiece was constructed in the facade in 1866. The cathedral houses
crypt chambers, the most notable of which is the Bolívars', as his parents and young bride are entombed here. until 1948. In 1974, the cathedral parish's marriage registry for the period 1615–1831 was published by the
Instituto Venezolano de Genealogia. ==Architecture and fittings==