Granderson signed with the
New Orleans Saints as an
undrafted free agent following the
2019 NFL draft on May 10, 2019. He received a $15,000
signing bonus and a base salary guarantee of $70,000. Granderson was placed on the reserve/did not report list on July 18, while serving his prison sentence. He was reinstated from the "did not report" list and given a roster exemption on August 31, after his release from jail. Granderson was placed on the active roster on September 16. On March 10, 2022, Granderson signed a two-year contract extension with the Saints. He played in 16 games with four starts in 2022, recording 53 tackles and 5.5 sacks, good for fourth on the team. On September 23, 2023, Granderson signed a four-year, $52 million contract extension with the Saints. In 2025, Granderson transitioned from a full-time starter into a rotational role for New Orleans. He appeared in all 17 of the team's games (including six starts, recording four pass deflections, six sacks, and 57 combined tackles. In the Saints' season finale against the
Atlanta Falcons, Granderson recorded his first career interception on a
Kirk Cousins pass intended for
Kyle Pitts. ==NFL career statistics==