Manicone began his footballing career Switzerland with Team Ticino, before joining the youth academies of
Juventus and
Empoli in Italy. After being the player of the tournament for Empoli in the
Torneo di Viareggio, on 27 July 2017 Manicone signed a four-year contract with
Lugano. Manicone made his professional debut for Lugano in a 1–0
Swiss Super League to
St. Gallen on 16 August 2017. He injured the
anterior cruciate ligament of his knee in the last matchday of the 2017–18 season, and was successfully operated requiring a recovery period of 6 months. On 23 January 2019, Manicone was loaned out to
Chiasso for the rest of the season. On 2 September 2019, he joined Italian club
Bisceglie on loan. On 22 January 2020, he moved on another
Serie C loan to
Pianese. On 6 October 2020, he was loaned to
Serie C club
Grosseto. On 7 January 2021, he returned to
Chiasso on another loan. In July 2022, he made a permanent move to Chiasso. In February 2023, Manicone moved to
SC Kriens. In July 2023, Manicone joined Italian
Serie D club
Varesina. ==Personal life==