Early work and breakthrough Vesga's career began when he returned to Colombia and was cast in the telenovela
Pobre Pablo (2000). He steadily built a reputation as a
character actor, avoiding the typical heartthrob ("galán") stereotype, while securing significant roles. His major breakthrough came in 2010 with the hit series
Amor sincero, a biopic of the singer
Marbelle. Vesga played Samuel Medina, the protagonist's father. The role was a cultural phenomenon in Colombia; despite playing a father figure rather than a romantic lead, the character became incredibly popular with female audiences for his portrayal of an ideal husband. For this performance, he won the India Catalina Award for Best Leading Actor in a Telenovela in 2011.
Villain roles and international success Vesga transitioned to playing antagonists, gaining critical acclaim for his "hated" villain roles. Notable antagonistic performances include Alejandro Sanjuán in
La prepago (2013) and the sadistic "Picasso" in
El Bronx (2019). In 2024, he achieved widespread recognition for playing two major villains simultaneously on Colombian television: Alfredo Azcárate in
Devuélveme la vida and Francisco "El Flaco" Marulanda in the
Netflix survival thriller
The Hijacking of Flight 601 (
Secuestro del vuelo 601). The latter became one of Netflix's most-watched non-English series globally that year. In 2025, it was announced that Vesga would be joining the cast of
Pluribus, a series by
Breaking Bad creator
Vince Gilligan. He plays the role of Manousos Oviedo, one of the few people immune to an alien virus that has overtaken the world, who refuses contact with the infected. == Personal life ==