Club career Matheu made his professional debut in 2004 in
Club Atletico Independiente, and soon established himself as a member of the first team squad. In the
Apertura 2007 he chipped in with 4 goals in 15 games, a useful return for a defender. He nearly moved to
Lokomotiv Moscow for $3.3million (£1.6million) in July 2008 but chose to play for
Cagliari instead. He was now repurchased by
Independiente for 1.5 million dollars for the 50% of his rights (Independiente already owned 50%). After one season in Italy, he returned to Independiente. At the end of the 2011–12 season, Matheu's contract expired and he returned to Italy, signing a contract with
Atalanta. On 30 August 2013, the
Siena board announced the loan signing of Matheu until the end of the season. On 1 January 2016, Matheu signed for Argentine club
CA Banfield.
International career Matheu received his first call-up to the
Argentina squad for the friendly against
Costa Rica on 26 January 2010. ==Honours==