In 1991, Menoni joined the faculty at
Colorado State University as a teaching assistant. She led the
National Science Foundation centre for Extreme Ultraviolet (EUV) Science and Technology with her husband,
Jorge Rocca. At
Colorado State Menoni investigated the physics of semiconductors and optically active materials. In the 1990s, Menoni established XUV Lasers, a spin-out company that sought to commercialize her innovations in laser science. Menoni studied multi-layer oxide materials that can act as
anti-reflective coatings for high power lasers. In 2008, she developed a table-top microscope that uses
extreme ultraviolet lasers and sophisticated lasers to image nanoscale objects. The laser pulse, which had around a nanosecond duration, could image structures with a spatial resolution of ≈ 0.05 μm. She produces the anti-reflection coatings through
ion beam sputtering. == Awards and honors ==