Melgrati was born in
Milan and had a successful amateur career. In 2020, she won the Italian Ladies Match Play Championship and the Italian Ladies U18 Championship, and was stroke-play qualifying co-medalist at
The Women's Amateur Championship. In 2021, she was runner-up at the Italian International Ladies Amateur Championship two strokes behind
Charlotte Liautier, and top-6 at both the
Spanish International Ladies Amateur Championship and
Portuguese International Ladies Amateur Championship. She finished top-10 at the
European Ladies Amateur in 2022 and 2023. With Moresco and Nobilo she secured the bronze at the 2019
World Junior Girls Championship in Canada. She also represented Europe at the 2025
Patsy Hankins Trophy. Melgrati attended the
University of Arizona from 2021 to 2025 and played for the
Arizona Wildcats women's golf team, where she was WGCA Honorable Mention All-American and
Pac-12 All-Conference Team Selection. She appeared at the
Augusta National Women's Amateur three times. In 2021, Melgrati finished tied for 10th at the
Ladies Italian Open. In 2022, she finished tied 4th at the Ladies Italian Open before shooting an opening round 65 (−7) to share the overnight lead at the
Scandinavian Mixed, a
European Tour and
Ladies European Tour joint event. She was tied for second after 36 holes, and ultimately finished tied 20th. ==Professional career==