The thirty-fifth series of
Casualty features a cast of characters working for the NHS within the emergency department of
Holby City Hospital and the
Holby Ambulance Service. Most cast members from the
previous series reprise their roles in this series. William Beck appears as Dylan Keogh, a
consultant in
emergency medicine, while Di Botcher portrays Jan Jenning, the operational duty manager at Holby Ambulance Service. Stirling Gallacher plays Ffion Morgan, a
police officer, and
Jacey Sallés portrays
Rosa Cadenas, a
healthcare assistant. Mealing confirmed on 24 December 2020 that a regular character would be
killed off in the opening episode after contracting coronavirus. The episode features the death of Noel, whose identity was embargoed until transmission. Preece called Marshall, who has appeared in the show since 2008, "a much loved member of the behind-the-scenes
Casualty family" and expressed her sadness at the character's death. She added that many people cried when filming Marshall's final scenes and that he would be missed. Nolan's departure from the series was revealed on 31 December 2020, and Will departs in the third episode. In March 2021, it was confirmed that at Mealing's request, Connie would depart the series, after a seven-year stint. The exit was reported to be a temporary break. Mealing expressed her delight at playing Connie and felt that the character was revolutionary for women. Deborah Sathe, the senior head of content production at BBC Studios, praised Connie and Mealing, in particular for her work following the show's return to filming. Connie departs in the thirteenth episode after deciding to be closer to her daughter in America. The casting of actor
Bobby Lockwood in the role of paramedic
Leon Cook was announced on 16 December 2020. He is billed as "handsome, charming, loveable" whose "endless excitement" can cause tension with some colleagues. Lockwood expressed his pride at representing front line workers in his role. Preece was pleased with Lockwood's casting and liked the character. She opined that both Lockwood and Leon have "the most extraordinary comic timing". Leon departs after failing to secure a permanent position at the ambulance service. Preece thanked Lockwood for his work and suggested that the character could return in the future. On 20 May 2021, it was announced that Osi Okerafor had been cast as
Matthew Afolami, an experienced locum registrar. His backstory states that he was in a relationship with Fenisha, which creates drama in her ongoing romance with Ethan. Okerafor liked his character's patient care. Preece was pleased to have Okerafor, who she described as "handsome and debonair, sensitive and steadfast, passionate and unpredictable", join the cast. reprised her role as
Grace Beauchamp-Strachan in the series. Preece confirmed that multiple former cast members would return to
Casualty during the series. She expressed her delight at the returns and revealed that one return would "[come] from a very unexpected direction". The character returns in episode 14. James' agent confirmed that she had been promoted to the regular cast. The return of
Ciaran Coulson, portrayed by
Rick Warden, was announced on 12 March 2021. Warden played Ciaran in
series 33. The series features several recurring characters and multiple guest stars. It was announced on 3 February 2020 that Chris Gordon would reprise his role as Ross West, the son of Jan, as part of "a huge and terrifying story" involving the character and Ffion. He returns in episode nine, and departs in episode seventeen. In October 2020, Gallacher revealed, via
Twitter, that comedian
Rosie Jones would guest star in an episode of the series. She portrays patient Paula Kettering. Preece confirmed that she would appear in the ninth episode and the role would showcase a "whole new side" of Jones. She added that her character would appear with Jan. McKenzie appeared again in episode twelve. Episode five features an appearance from
Philip Wright as Graham Kirkby, the father of Marty. He has appeared on a recurring basis since series 33. Kriss Dosanjh reprises his role in episode 13 as Rash's father, Ashok Masum; he previously appeared in series 34. Graham returns in the fifteenth episode, alongside Marty's mother, Bibi Kirkby, who is portrayed by Fisun Burgess.
Main characters •
William Beck as
Dylan Keogh •
Di Botcher as
Jan Jenning •
Olivia D'Lima as
Fenisha Khatri (until episode 30) •
Jason Durr as
David Hide •
Uriel Emil as
Lev Malinovsky (until episode 30) •
Amanda Henderson as
Robyn Miller •
Shaheen Jafargholi as
Marty Kirkby • Adele James as Christina "Tina" Mollett (from episode 5) •
Gabriella Leon as
Jade Lovall •
Bobby Lockwood as
Leon Cook (episodes 2−17) •
Tony Marshall as
Noel Garcia (until episode 1) •
Amanda Mealing as
Connie Beauchamp (until episode 13) •
Kirsty Mitchell as
Faith Cadogan •
Neet Mohan as
Rash Masum •
Jack Nolan as
Will Noble (until episode 3) • Osi Okerafor as
Matthew Afolami (from episode 22) •
George Rainsford as
Ethan Hardy •
Michael Stevenson as
Iain Dean (from episode 14) •
Derek Thompson as
Charlie Fairhead •
Charles Venn as
Jacob Masters Recurring characters •
Emily Carey as
Grace Beauchamp-Strachan (episodes 7−13) •
Harry Collett as
Oliver Hide •
Stirling Gallacher as
Ffion Morgan • Lollie McKenzie as Natalia Malinovsky •
Jacey Sallés as
Rosa Cadenas •
Rick Warden as
Ciaran Coulson Guest characters •
Leslie Ash as
Vanessa Lytton • Fisun Burgess as Bibi Kirkby • Kriss Dosanjh as Ashok Masum •
Chris Gordon as Ross West •
Rosie Jones as Paula Kettering •
Philip Wright as Graham Kirkby == Episodes ==