Cathedral High School teams are known as the "Panthers". They compete as a member of the Massachusetts Interscholastic Athletic Association (MIAA) Division IV and in the
Catholic Central League. Boys' sports include football, basketball, and baseball. Girls' sports include volleyball, basketball, softball, and cheerleading. Coed teams include soccer, indoor track, and outdoor track. The boys' basketball squad has established a strong reputation as one of the premier small school basketball teams in the state. The Panthers have appeared in five Division IV State Championship games (2006, 2007, 2009, 2010, 2012). The team won their division's state championship in 2006, 2007, and 2009. They were also South Sectional Finalists in 2011, and were Division 4 State Semi-Finalists in 2014. The girls' basketball team has achieved huge success in recent years under Head Coach, Clinton Lassiter. The team has won the Division IV State Championship multiple times, including most recently, back-to-back wins in 2023 and 2024. They also lead their division in 2016, 2017, 2019 and 2020.
Football Cathedral's football team has also developed a strong reputation in Boston recently. Under the leadership of then Head Coach Duane Sigsbury, the Panthers appeared in back-to-back Division 4A State Championship games in 2011 and 2012, winning the State Championship in 2012 with an overtime win against
Madison Park. Kadeem Edge, a wide receiver on the 2012 championship team, was selected as a Boston Herald All-Scholastic and was also named a Catholic Central Small All-Star. Also, Panthers defensive lineman Mohammed Braimah was named the Catholic Central MVP, and was also selected as a member of the Boston Globe All-State Team and was named a Boston Globe All-Scholastic. Further honors for the 2012 Cathedral football team also included Sean Elad as the Catholic Central Small Defensive MVP, and Derek Welcome as the Catholic Central Small Defensive Lineman of the Year. Also with the rise of the Class of 2015 who went 41–9 in their tenure at Cathedral included Kejonte Hickman, Jermal Jackson, Justice Turner, Elijah Marcelo, Trehme Haney, Bryan Cedeno and Khalik Clerville.
2011 State Championship "Celebration" Controversy In 2011, the football team nearly won the MIAA Division 4A State Championship, but lost due to a controversial official's call which overturned a potential game-winning touchdown in the final minutes. Midway through the 4th quarter, Cathedral trailed
Blue Hills by a score of 16–14 in the Division 4A State Championship game. With approximately six minutes remaining in the game, Cathedral quarterback Matt Owens raced around the right side of the line and split the defense for a potential 56-yard game-winning touchdown run. At around the 20-yard line, Owens raise one of his arms in celebration before crossing the goal line. The referees threw a flag on the play and called an unsportsmanlike penalty on Owens, which negated the touchdown and moved the Panthers back fifteen yards from the original line of scrimmage. On the next play, Cathedral turned the ball over to Blue Hills, and they eventually ran the clock out to secure a 16–14 win over Cathedral. In the aftermath, Boston mayor
Thomas Menino was critical of the call and invited the entire Cathedral football team to lunch. Furthermore,
Skip Bayless and
Stephen A. Smith debated the controversial call on
ESPN TV series,
First Take on December 6, 2011. The story made national headlines and was covered by sources across the nation. The following season in 2012, the Panthers returned to the Division 4A State Championship game, where they defeated Madison Park by a score of 22–20 in overtime. The school honors alumni-athletes and supporters biennially in a hall of fame induction, among which is notable class of 1984 alumna and WNBA player
Michelle "Ice" Edwards.
Tufts Medical Center partners with Cathedral to provide athletic training services and team physicians to serve at home games. Tufts also conducts free annual sports physicals and weekly clinics to assess and serve student athletes. ==Extracurricular Activities==