DeAngelis was able to implement some of her ideas for improving health care when she took her first faculty position at the
Columbia College of Physicians. Her next appointment was at the
University of Wisconsin. In 1978, DeAngelis returned to Johns Hopkins as the head of the general pediatrics and adolescent medicine division. In 1984, she was promoted to full professor, the twelfth woman to attain this distinction in the school's history. DeAngelis was the deputy head of the Johns Hopkins Children's Center. She has served as an expert witness in court cases involving pediatric medical issues, including the high-profile
Elizabeth Morgan case. DeAngelis became the vice dean for academic affairs and faculty at the Johns Hopkins School of Medicine in 1990. Under her guidance and interest in issues involving women in academia, further opportunities for women were nurtured and many women became full professors. She received a grant and directed the program to introduce a new curriculum for the medical school, emphasizing "hands-on experience and contact with patients," beginning in 1992. In 1999, DeAngelis was appointed editor of the Journal of the American Medical Association, and
Janice E. Clements succeeded DeAngelis as vice dean. DeAnglis stepped down as Editor-in-Chief of JAMA in July 2011. She returned to Johns Hopkins University where she serves in a number of capacities, including special advisor to the Dean and served as president of the Alpha of Maryland chapter of
Phi Beta Kappa. ==Author and editor==