The Cavendish Laboratory has had an important influence on
biology, mainly through the application of
X-ray crystallography to the study of structures of biological molecules.
Francis Crick already worked in the Medical Research Council Unit, headed by
Max Perutz and housed in the Cavendish Laboratory, when
James Watson came from the United States and they made a breakthrough in discovering the structure of
DNA. For their work while in the Cavendish Laboratory, they were jointly awarded the Nobel Prize in Physiology or Medicine in 1962, together with
Maurice Wilkins of
King's College London, himself a graduate of
St. John's College, Cambridge. The discovery was made on 28 February 1953; the first Watson/Crick paper appeared in
Nature on 25 April 1953. Sir
Lawrence Bragg, the director of the Cavendish Laboratory, where Watson and Crick worked, gave a talk at
Guy's Hospital Medical School in London on Thursday 14 May 1953 which resulted in an article by Ritchie Calder in the
News Chronicle of London, on Friday 15 May 1953, entitled "Why You Are You. Nearer Secret of Life." The news reached readers of
The New York Times the next day;
Victor K. McElheny, in researching his biography,
Watson and DNA: Making a Scientific Revolution, found a clipping of a six-paragraph
New York Times article written from London and dated 16 May 1953 with the headline "Form of `Life Unit' in Cell Is Scanned." The article ran in an early edition and was then pulled to make space for news deemed more important. (
The New York Times subsequently ran a longer article on 12 June 1953). The Cambridge University undergraduate newspaper
Varsity also ran its own short article on the discovery on Saturday 30 May 1953. Bragg's original announcement of the discovery at a
Solvay Conference on
proteins in Belgium on 8 April 1953 went unreported by the British press.
Sydney Brenner,
Jack Dunitz,
Dorothy Hodgkin,
Leslie Orgel, and Beryl M. Oughton, were some of the first people in April 1953 to see the model of the structure of
DNA, constructed by Crick and Watson; at the time they were working at the
University of Oxford's Chemistry Department. All were impressed by the new DNA model, especially Brenner who subsequently worked with Crick at
Cambridge in the Cavendish Laboratory and the new
Laboratory of Molecular Biology. According to the late Dr. Beryl Oughton, later Rimmer, they all travelled together in two cars once Dorothy Hodgkin announced to them that they were off to Cambridge to see the model of the structure of DNA. Orgel also later worked with Crick at the
Salk Institute for Biological Studies. ==Present site==