The building is the oldest on the island, dating from the 1830s - one of only a handful of structures which date from the 19th century that remain. The museum's beginnings can be traced to the 1930s when local resident Ira Thompson began collecting Caymanian artifacts as a hobby; in 1979, the government purchased Thompson's collection and it now encompasses a major portion of the museum's collection.
Margaret Leshikar-Denton was appointed as the museum's director in 2011, having first started working for the museum in 1986. In 2015, a commemorative coin was minted to celebrate the 25th anniversary of the museum. ==Exhibits==