The earliest settlement in the current area of Cayo Hueso dates back to the second half of the 16th century, following the burning of Havana by French pirate
Jacques de Sores. It wasn't until 1912 that the area was officially recognized as the neighbourhood of Cayo Hueso. Its name, which means "bone
cay", derives from the fact that the
Espada Cemetery was located there; it was demolished in 1908. Among the oldest institutions in the area were the leprosy hospital (demolished in 1916), the
Casa de Beneficencia orphanage (replaced by the Hermanos Ameijeiras hospital), and the San Dionisio mental asylum which operated between 1828 and 1860. The asylum was located between the cemetery and the San Lázaro hospital, and named after the then governor of Cuba,
Francisco Dionisio Vives. Modern sights include the
art deco Edificio Solimar, built in 1944; the Casa Marina, a former brothel; and the Fragua Martiana Museum, dedicated to the "father" of the Cuban nation,
José Martí. In 1988, Cayo Hueso was one of the first three neighbourhoods to take part in the
Talleres de Transformación Integral de los Barrios (Comprehensive Workshops for Neighborhood Change). Between 1995 and 1999, an urban health improvement project, known as Plan Cayo Hueso, was developed. Since the 1990s many environmental initiatives have taken place in the ward. ==Culture==