This gene encodes a member of the
beta chemokine receptor family, which belongs to
G protein-coupled receptors. The ligands of this receptor include
CCL3 (or MIP-1 alpha),
CCL5 (or RANTES),
CCL7 (or MCP-3), and
CCL23 (or MPIF-1).
Chemokines and their receptors, which mediate
signal transduction, are critical for the recruitment of effector
immune cells to the site of
inflammation.
Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including
CCR2,
CCRL2,
CCR3,
CCR5 and
CXCR1, are found to form a gene cluster on chromosome 3p. == Interactions ==