Dekker started his research on single
carbon nanotubes in 1993 when he set up a new line of research to study electrical transport through single organic molecules between nanoelectrodes. In 1996 a breakthrough was realized with carbon nanotubes. This was achieved in a collaboration with the group of Nobel laureate
Richard Smalley.
STM and
nanolithography techniques were used to demonstrate that these nanotubes are
quantum wires at the single-molecule level, with outstanding physical properties. Many new phenomena were discovered, and he and his research group established a leading position in this field of research. Dekker and his research group discovered new physics of nanotubes as well as explored the feasibility of
molecular electronics. In 1998, they were the first to build a
transistor based on a single nanotube molecule. Since 2000, Dekker has shifted the main focus of his work towards
biophysics where he studies the properties of single
biomolecules and
cells using the tools of
nanotechnology. This change of field was driven by his fascination for the remarkable functioning of biological molecular structures, as well as by the long-term perspective that many interesting discoveries can be expected in this field. Current lines of research in his biophysics group are in the areas of: Thirteen of his group's publications have been cited more than 1000 times, and in 2001, his group work was selected as
Breakthrough of the Year by the journal
Science.
Other interests Dekker is a
Christian and active in the discussion about the relationship between science and religion, a topic on which he has co-edited several books. In 2005 Dekker became involved in Netherlands-wide discussions about Intelligent Design, a movement that he has since clearly distanced himself from. Dekker advocates that science and religion are not in opposition but can be harmonized. He wrote the foreword to the Dutch translation of ‘The Language of God' by
Francis Collins, the former director of the
National Institutes of Health. Like Collins, Dekker is a proponent of
theistic evolution. He actively debates with creationists in the Netherlands. In 2015 he co-wrote a children's book that explained an
evolutionary creation to young children. This got translated in English as 'Science Geek Sam and his Secret Logbook'.{{cite web|author= |url= https://biologos.org/resources/science-geek-sam-and-his-secret-logbook| title= Children book: Science geek Sam and his secret logbook ==References==