Genome-wide association studies identified an association between
body mass index and two loci near the
CADM1 and
CADM2 gene. Experimental results of another study showed that obese mice had an over expression of both
CADM1 and
CADM2 genes, and that loss of
CADM1 protected mice from obesity, promoting a negative energy balance and weight loss. Furthermore, a 2019
GWAS study revealed an association between
Anorexia nervosa and
CADM1. In the brain, this genes mediate synaptic assembly, and mutations in
CADM1 are also associated with
Autistic spectrum disorder. ==See also==