The school began as St. Mary's Institute on March 25, 1852 in rented rooms above a blacksmith's shop on
Military Plaza. The original faculty consisted of Brother Anthony Edel (Founder, First Superior, and First Principal) from Ohio, three
Marianist Brothers from
Bordeaux,
France (Nicholas Koenig, Jean-Baptiste Laignounse, and Xavier Mauclerc), and Timothy O'Neil, a layman from San Antonio. The school moved to a new two-story building at 112 College Street on March 1, 1853. In 1891, the school was renamed St. Mary's College, reflecting its expansion to include boarders and primary and middle school grades. In 1923, the school added boarding students from St. Louis College and was renamed St. Mary's Academy. The site is now a hotel entryway, recognized by Texas Historical Marker #3819 as the location of Old St. Mary's College, or "The Old Academy." In 1932, the school relocated to the current three-story
art deco brick building on at 1403 N. St. Mary's Street and was renamed once more to Central Catholic School. Classrooms were added to the unfinished third floor in the late 1940s. of the presidency, the school's name was changed back to Central Catholic High School. The football field and track were added in the 1980s, and the former activity center became the school's band hall by the 1990s. the campus occupies . The school expanded in 2013 with the addition of a new library and eight new classrooms attached to the main building, comprising . Central Catholic is one of the oldest high schools in San Antonio, and it counts many prominent business and political leaders among its alumni. It was the first all-boys school in San Antonio and remains one of the largest all-male schools in Texas. Historical Marker #788 on the school's front lawn describes the school's history and denotes it as a Texas landmark. ==Mascot==