The chemical synthesis has been described: Starting material: Product of first step: 2,6-Di-tert-butylphenol is treated with formaldehyde, base and methanol to give [87-97-8] (2). Base catalyzed reaction with isobutaldehyde gives CGP-13501 (3). Hydride reduction of the aldehyde gives the primary alcohol. According to Krysin (Russia),
2,6-Di-tert-butylphenol is reacted with
Neopentyl glycol with lye in an autoclave. Although 1 step reaction, yield was quoted as merely 15%. ==See also==