The club's parent athletic association, G.S. Charilaos Trikoupis Messolonghi (Γ.Σ. Χαρίλαος Τρικούπης Μεσολογγίου) was founded in 1955. The men's basketball section of the club was founded in 1959. From 1959 to 1971, the club organized local basketball tournaments and competed in
friendly games. From 1971 to 1982, the club competed in local minor league competitions. Starting with the 1982–83 season, the club began to compete in the regional minor league Association of Basketball Clubs of Northwestern Greece, or E.S.KA.V.D.E. (Ε.Σ.ΚΑ.Β.Δ.Ε). For the 1993–94 season, the club was
promoted up to a Greek national competition for the first time, as it joined the
Greek 4th Division. The club stayed in the Greek 4th Division for five straight seasons, through the 1997–98 season. After that, the club again played in the local and regional competitions. For the 2015–16 season, Trikoupis rejoined the Greek 4th Division. The club then played in the
Greek 3rd Division for the first time, in the 2016–17 season. Trikoupis then competed in the
Greek 2nd Division for the first time, in the
2018–19 season. The team then managed to win the Greek 2nd Division championship, in the
2019–20 season, with a 19–2 league record, and thus earn a league promotion up to the top-tier level
Greek Basket League, for the following season. Trikoupis then competed in the Greek 1st Division, for the first time, in the
2020–21 season. ==Arena==