Wesley became an ordained minister of the
African Methodist Episcopal Church (AME). He also had an academic career as a professor of history and wrote a total of more than 15 books on African-American history and political science. He served as the Dean of the Liberal Arts and the Graduate School at
Howard University. He won a
Guggenheim Fellowship that enabled him to travel in 1931 to
London, England, where on March 31 he was present with
Harold Moody at the founding of the
League of Coloured Peoples that was inspired in part by the
NAACP, of which Wesley was a member. In 1942 Wesley was called as President of Wilberforce University (an AME-affiliated university) in
Wilberforce, Ohio, serving until 1947. That year, he founded
Central State University across the street from Wilberforce. He served as its president until 1965, when he returned to Washington, D.C. ==Awards==