Rofer's early research considered photochemistry and how it can be used to understand uranyl compounds in organic solvents. She later developed spectroscopic tools for isotope separation. In the wake of the
Soviet occupation of
Estonia and
Kazakhstan, Rofer became involved in environmental remediation. After retiring from Los Alamos National Laboratory in 2001 Rofer became involved in documenting the
Manhattan Project. She maintains a blog on nuclear physics (
Nuclear Diner) which provides a critical analysis of the likelihood of nuclear terrorism. She has also contributed to newspapers including
The Globe and Mail,
The Washington Post and
Mother Jones. When asked about the
2022 Russian invasion of Ukraine, Rofer told
Chemistry World, "Obviously, you don’t want nuclear reactors in the middle of a war. But here we are". She has written opinion pieces for
Nature,
BuzzFeed and
HuffPost. == Selected publications ==