Nodule A
lung nodule is a discrete opacity in the lung which may be caused by: •
Neoplasm: benign or malignant • Granuloma:
tuberculosis • Infection:
round pneumonia • Vascular:
infarct,
varix,
granulomatosis with polyangiitis,
rheumatoid arthritis There are a number of features that are helpful in suggesting the diagnosis: • rate of growth • Doubling time of less than one month: sarcoma/infection/infarction/vascular • Doubling time of six to 18 months: benign tumor/malignant granuloma • Doubling time of more than 24 months: benign nodule neoplasm •
calcification • margin • smooth • lobulated • presence of a corona radiata • shape • site If the nodules are multiple, the differential is then smaller: • infection:
tuberculosis, fungal infection,
septic emboli • neoplasm: e.g.,
metastases,
lymphoma,
hamartoma •
sarcoidosis •
alveolitis • auto-immune disease: e.g.,
granulomatosis with polyangiitis,
rheumatoid arthritis • inhalation (e.g.,
pneumoconiosis)
Cavities A cavity is a walled hollow structure within the lungs. Diagnosis is aided by noting: • wall thickness • wall outline • changes in the surrounding lung The causes include: •
cancer •
infarct (usually from a pulmonary embolus) • infection: e.g.,
Staphylococcus aureus,
tuberculosis,
Gram negative bacteria (especially
Klebsiella pneumoniae), anaerobic bacteria, and fungus •
Granulomatosis with polyangiitis Pleural abnormalities Fluid in space between the lung and the chest wall is termed a
pleural effusion. There needs to be at least 75 mL of pleural fluid in order to blunt the
costophrenic angle on the lateral chest radiograph and 200 mL of pleural fluid in order to blunt the
costophrenic angle on the posteroanterior chest radiograph. On a lateral decubitus, amounts as small as 50ml of fluid are possible. Pleural effusions typically have a
meniscus visible on an erect chest radiograph, but loculated effusions (as occur with an
empyema) may have a
lenticular shape (the fluid making an
obtuse angle with the chest wall). Pleural thickening may cause blunting of the costophrenic angle, but is distinguished from pleural fluid by the fact that it occurs as a linear shadow ascending vertically and clinging to the ribs.
Diffuse shadowing The differential for diffuse shadowing is very broad and can defeat even the most experienced radiologist. It is seldom possible to reach a diagnosis on the basis of the chest radiograph alone: high-resolution
CT of the chest is usually required and sometimes a lung
biopsy. The following features are usually noted: • type of shadowing (lines, dots or rings) • reticular (crisscrossing lines) •
companion shadow (lines paralleling bony landmarks) • nodular (many small dots) • rings or cysts • ground glass • consolidation (diffuse opacity with air bronchograms) • location (where is the lesion worst?) • upper (e.g.,
sarcoid,
tuberculosis,
silicosis/
pneumoconiosis,
ankylosing spondylitis,
Langerhans cell histiocytosis) • lower (e.g.,
cryptogenic fibrosing alveolitis,
connective tissue disease, asbestosis, drug reactions) • central (e.g.,
pulmonary edema,
alveolar proteinosis,
lymphoma,
Kaposi's sarcoma,
PCP) • peripheral (e.g.,
cryptogenic fibrosing alveolitis,
connective tissue disease,
chronic eosinophilic pneumonia,
bronchiolitis obliterans organizing pneumonia) • lung volume • increased (e.g.,
Langerhans cell histiocytosis,
lymphangioleiomyomatosis,
cystic fibrosis,
allergic bronchopulmonary aspergillosis) • decreased (e.g., fibrotic lung disease, chronic sarcoidosis, chronic extrinsic allergic alveolitis)
Pleural effusions may occur with cancer, sarcoid, connective tissue diseases and
lymphangioleiomyomatosis. The presence of a pleural effusion argues against pneumocystis pneumonia. ;Reticular (linear) pattern :(sometimes called "reticulonodular" because of the appearance of nodules at the intersection of the lines, even though there are no true nodules present) :*
idiopathic pulmonary fibrosis :*
connective tissue disease :*
sarcoidosis :*radiation fibrosis :*
asbestosis :*
lymphangitis carcinomatosa :*
PCP ;Nodular pattern :*
sarcoidosis :*
silicosis/pneumoconiosis :*
extrinsic allergic alveolitis ;*
Langerhans cell histiocytosis ;*
lymphangitis carcinomatosa ;*
miliary tuberculosis ;*
metastases ;Cystic :*
cryptogenic fibrosing alveolitis (late stage "honeycomb lung") :*cystic
bronchiectasis :*
Langerhans cell histiocytosis :*
lymphangioleiomyomatosis ;Ground glass :*
extrinsic allergic alveolitis :*
desquamative interstitial pneumonia :*
alveolar proteinosis :*
infant respiratory distress syndrome (RDS) ;Consolidation :*
pneumonia :*alveolar haemorrhage :*
alveolar cell carcinoma :*
vasculitis Signs :*The
silhouette sign is especially helpful in localizing lung lesions. (e.g., loss of right heart border in right middle lobe pneumonia), :*The air bronchogram sign, where branching radiolucent columns of air corresponding to bronchi is seen, usually indicates air-space (alveolar) disease, as from blood, pus, mucus, cells, protein surrounding the air bronchograms. This is seen in
Respiratory distress syndrome ==Disease mimics==