The hospital, which was built on land donated by the
Archbishop of Dublin, was designed by Robinson Keefe Devane and officially opened as Our Lady's Hospital for Sick Children in 1956. The hospital changed its name to "Our Lady's Children's Hospital, Crumlin" in 2005. In November 2012 the
Minister for Health James Reilly announced plans to transfer the hospital's services to
a new children's hospital on the campus of
St. James's Hospital. In July 2013 concerns were raised about children who underwent a colonoscopy at the hospital between 17 May and 5 July 2013; it was revealed they had been exposed to an infection that could not be cured by antibiotics. The hospital changed its name from Our Lady's Children's Hospital, Crumlin to Children's Health Ireland at Crumlin as part of the rebranding of three hospitals under the Children's Health Ireland banner on 1 January 2019. As of late October 2020, the hospital had failed to make several of its clinical trial results public as required by European Union transparency rules. ==All-Ireland champions==