Discovered in 2003 after going through his first major audition, Lowell landed the role of Jonathan Fields on the
ABC teen
drama Life As We Know It. In 2006, Lowell had lead roles in the
coming-of-age film
Graduation and also in a small film entitled
You Are Here. After the end of
Life As We Know It, Lowell was cast as
Stosh "Piz" Piznarski in the third season of
Veronica Mars, opposite
Kristen Bell and
Jason Dohring. In 2009 Chris Lowell appeared in several videos by the sketch comedy group
BriTANicK, including "Pillow Talk", and "The Morning After." From 2007 until 2010, Lowell appeared in the ABC drama
Private Practice, alongside
Kate Walsh,
Audra McDonald, and
Tim Daly, playing Dell, the receptionist for the Oceanside Wellness Group who was also a qualified nurse,
midwife-in-training, and young father to six-year-old daughter Betsy. Lowell exited
Private Practice in the show's third-season finale when Dell died from heart failure, a complication during brain surgery after a vehicle accident. In 2011, Lowell played the role of Stuart Whitworth in the film
The Help, an
adaptation of
Kathryn Stockett's
2009 novel of the same name. The following year, filming began on Lowell's directorial debut,
Beside Still Waters. Set in Michigan’s Upper Peninsula, the film tells the story of a man redefining his outlook on life after the death of his parents. Lowell also played Derrick on Fox's 2014 comedy
Enlisted. Lowell is also a
vocalist and
harmonicist for the
indie acoustic band Two Shots for Poe. He starred in the Off-Broadway hit
Jacuzzi at
Ars Nova in New York City. In May 2021, Lowell was cast in the
How I Met Your Mother spinoff series
How I Met Your Father, led by
Hilary Duff. In November 2021, Duff and the cast confirmed via social media accounts that the series would premiere on January 18, 2022. On February 15, 2022, Hulu renewed the series for a 20-episode second season. He played the role of producer Sebastian “Bash” Howard in the 2017-19 Netflix series GLOW. ==Personal life==