Bezuidenhout turned professional in early 2015. He had success in September 2015 winning two 36-hole events on the
Big Easy Tour, losing in a playoff for the Big Easy Tour Championship and also winning the Order of Merit. In December 2015, Bezuidenhout won the Sunshine Tour Q School. In the first event of the season, the 2016
BMW SA Open, co-sanctioned with the
European Tour, he finished runner-up to
Brandon Stone. Later in 2016, he won a smaller tournament on the Sunshine Tour, the
Sun Fish River Challenge, and finished runner-up in the
Vodacom Origins of Golf Final. Bezuidenhout started 2017 with 5th-place finishes in both the
Eye of Africa PGA Championship and the
Dimension Data Pro-Am. He was the
2016–17 Sunshine Tour Rookie of the Year, awarded the Bobby Locke Trophy. Bezuidenhout played several
2017 Challenge Tour events. He finished tied for 25th place in the
European Tour Q-School to gain a place on the main tour for 2018. Bezuidenhout made the cut in 20 of his 26 2018 European Tour starts. His best finish was tied for 17th place, and he finished 105th in the Order of Merit, just retaining his card for 2019. Bezuidenhout was one of nine runners-up in the 2019
Commercial Bank Qatar Masters behind
Justin Harding. He also tied for 4th place in the
Hero Indian Open and third place in the
BMW International Open. The following week he won the
Estrella Damm N.A. Andalucía Masters and with the win earned entry into the
2019 Open Championship. In November 2020, Bezuidenhout won the
Alfred Dunhill Championship at
Leopard Creek Country Club. A final round 69 was good enough to help him win by four shots. 54-hole leader
Adrian Meronk let his lead slide by shooting a final round 76. A week later, Bezuidenhout claimed a wire-to-wire victory at the
South African Open which was played at
Gary Player Country Club. He became the first player with back-to-back victories on the European Tour since
Justin Rose in 2017. Bezuidenhout recorded his best finish on the
PGA Tour in July 2022. He finished tied-second at the
John Deere Classic, three shots behind
J. T. Poston. This result also gave him a place in the
2022 Open Championship. In September 2022, Bezuidenhout was selected for the International team in the
2022 Presidents Cup; he played two matches, winning one and tying the other. In January 2024, Bezuidenhout tied his best finish on the PGA Tour with a runner-up finish at
The American Express; one shot behind amateur
Nick Dunlap. He claimed first place prize money due to Dunlap's amateur status. ==Professional wins (10)==