Camargo made his theatrical debut in 1999, starring in films such as
Plunkett & Macleane and
Harlem Aria, co-starring in the latter with
Damon Wayans and
Gabriel Casseus. He continued playing small roles in films, starring as Officer Pavel Loktev in
K-19: The Widowmaker (2002) and playing Detective Scott in
The Cry (2007). Camargo is perhaps best known for his role as Brian Moser, a.k.a. Rudy Cooper, the long-lost brother of the
titular character, in
Dexter, starring as a regular cast member in
Season 1 (2006). Brian is the enigmatic Ice Truck Killer, his main goal being to reunite with his brother by starting a series of murders to attract Dexter's attention while getting closer to him by dating his foster sister,
Debra Morgan, under his "Rudy Cooper" alias. Originally,
Jeremy Renner was considered for the role but declined due to scheduling conflicts. Camargo reprised the role as a guest star in
Season 2 (2007),
Season 6 (2011), and eventually in
Dexter: Resurrection (2025). Brian Moser's character received critical acclaim and is considered to be one of
Dexter's best villains, with Camargo's performance in particular being praised. Camargo continues to receive mementos from fans, including prosthetic hands with colored fingernails. Camargo's New York theater work includes the Public Theater's
Kit Marlowe, Steve Martin's
Underpants at
Classic Stage Company, and the title role of Theater For A New Audience's
Coriolanus. He made his broadway debut in 1996 as Edward Sergeant in
Skylight, which coincidentally had Camargo's
Dexter co-star
Michael C. Hall as his understudy. In 2008, Camargo played opposite
Dianne Wiest,
John Lithgow and
Katie Holmes in
Arthur Miller's All My Sons on
Broadway. In early 2009, he played the title role in the Theatre for a New Audience's production of
Hamlet. He won an Obie and Drama League nomination for his performance. The show ran until April 12, 2009. Camargo portrayed Orlando in The Bridge Project's presentation of Shakespeare's
As You Like It in Brooklyn, New York. In February 2010, he played Ariel in the company's rendition of Shakespeare's
The Tempest. Both plays were directed by British director
Sam Mendes. On September 30, 2010, he was cast as Eleazar Denali in
The Twilight Saga: Breaking Dawn,
Parts 1 and
2, playing alongside
Mía Maestro, who played Eleazar's wife, Carmen. Camargo wrote and directed
Days and Nights, a modern retelling of
Anton Chekhov's
The Seagull, produced by his wife, actress
Juliet Rylance, together with
Barbara Romer, founder of the New Globe Theater. The film was scheduled for a 2014 release. He portrayed
Mercutio in the 2013 Broadway revival of
Romeo and Juliet, directed by
David Leveaux and starring
Orlando Bloom as Romeo and
Condola Rashād as Juliet. He guest starred as antagonist Wade Crocker on the third season of
Syfy's
Haven and appeared on the
third season of
Elementary as Chris Santos. Camargo portrayed the title character of the Theatre for a New Audience off-Broadway production of
Pericles, directed by
Trevor Nunn, from February to April 2016. In May of that year he guest starred as
Dracula on the third season of
Showtime's
Penny Dreadful. In March and April 2017, Camargo portrayed a mid-career
Robert Evans in
Simon McBurney's stage adaptation of
The Kid Stays in the Picture, staged in London's
Royal Court Theatre. In the same year, he also starred in the
Netflix miniseries,
Wormwood. He also appeared as brutal military leader Tamacti Jun in the American TV show
See (2019-2022). In a separate interview, he talked about breaking out of being
typecast as a leading young man and finding enjoyment in playing villains such as psychopaths. In 2022, he played the main antagonist Mr. Aunspach in the horror film
Student Body. He also played in
Witch Hunt as witch hunter Detective Hawthorne. Camargo directed
The Last Manhunt (2022). Camargo originally joined the project as an actor, cast in the role of Sheriff Wilson. However, shortly before production began,
Jason Momoa—Camargo's
See co-star who co-wrote the screenplay and was originally slated to direct—stepped back due to scheduling conflicts. To prevent the film from being canceled, Camargo assumed directing responsibilities in addition to his role as the sheriff. Camargo aimed for diversity and representation of
Native American communities, stating "I really like making movies that people either love or hate, no in-between. If you like it, if you don't like the movie — doesn't matter. The Native community likes it. They feel heard, and the conversation has sort of corrected a little bit of history. So to me, anything [else] is just gravy.". In 2025, Camargo entered a development deal, partnering with Dimension Studio and Two Chairs Production for Camargo's planned television series,
Camelot. == Personal life ==