After basic work on the
immune defense of newborns and the early detection of
neonatal systemic infections, Speer became part of the inner circle of the "European Collaborative Study Group on
Surfactant Replacement" around Professors
Bengt Robertson and Tore Curstedt, both Stockholm as well as Henry L. Halliday, Belfast. Since that time he has been working on the clinical optimization of
surfactant treatment of
premature infants with respiratory distress syndrome; this therapy represents a milestone in neonatal medicine and has dramatically reduced the mortality of premature infants. In 1993, his research group succeeded in identifying a complex inflammatory response in the airways and lungs of preterm infants, which can progress into a chronic lung disease of preterm infants, the
bronchopulmonary dysplasia (BPD). These findings have opened the way for various
anti-inflammatory therapeutic strategies. In addition to his experimental work on the
etiopathogenesis of BPD, Speer's scientific work has focused on the role of pre- and postnatal infections of premature infants with
cytomegaloviruses and
ureaplasmas, among others. A variety of other activities describe Speer's scientific involvement: he is "joint Editor-in-Chief" of the journal
"Neonatology", co-editor of the "Zeitschrift für Geburtshilfe und Neonatologie" and he has served on numerous editorial boards of international scientific journals and scientific societies. He was secretary of the "Working Group on Neonatology" of the
"European Society for Pediatric Research" and president of the "European Association of Perinatal Medicine." In 2021, he was appointed "co-director" of the "Permanent School of Perinatal, Neonatal and Reproductive Medicine (PREIS School)" in Florence. Speer is a speaker at numerous congresses and symposia in Europe, North and South America, Asia, Australia, the Middle East and South Africa. In addition, he has regularly organized the international symposium "Recent Advances in Neonatal Medicine" since 1996. In spring 2016, he organized together with Prof. Bo Sun Shanghai the international congress "The Neonate - An International Symposium for Asia" in
Shanghai, China, for the first time, and the second edition in 2018. == Awards and member in scientific organizations ==