Radogno was educated in the Chicago area. She graduated from Lyons Township High School. She received both her Bachelor's and
Master's degree in Social Work from
Loyola University Chicago. Before entering politics, she worked as a social worker at Mercy Center for Health Care Services. Her interest in politics began when she decided to prevent the opening of a fire station on her street, and Radogno ran successfully for
Village of LaGrange Trustee (1989–1996). In 1996, she ran for the Illinois State Senate and narrowly defeated incumbent Robert Raica in the Republican primary.
In 2006, she was the Republican nominee for
Illinois State Treasurer and was defeated by
Democrat Alexi Giannoulias. On October 12, 2015, she was named as Illinois state chair of
John Kasich's
presidential campaign. On July 1, 2017, Rodagno resigned from the state Senate. ==Illinois Senate==