The location first opened in 1833 as the
Washington Medical College. The building was purchased by the Church Home Society of the Protestant Episcopal Church on 2 October 1857 and called the
Church Home and Infirmary.
Washington Medical College was the medical school connected with
Washington College of Pennsylvania (now part of the
Washington & Jefferson College).
Edgar Allan Poe (1809–1849) was taken to this location when he was found semiconscious and ill in a street gutter near East Lombard Street; this is where he subsequently died in October 1849.
Emily Nelson Ritchie McLean, who served as the seventh President General of the
Daughters of the American Revolution, died here on May 20, 1916. During the 1940s, Church Home and Hospital was one of three Baltimore hospitals providing a few beds for "colored" patients. In 1978, a plan to expand the hospital was opposed. ==Current usage of grounds==