Cipocereus crassisepalus grows tree-shaped, branches irregularly and reaches heights of up to 2 meters. The dark green, segmented shoots have a diameter of up to 6 centimeters. There are 4 to 6 blunt ribs that are thickened around the areoles. Thick, reddish-brown wool and bristly hair initially emerge from the round
areoles, which later turn gray until the areoles are finally bald. The initially shiny reddish-brown thorns turn gray with a darker tip. The 1 to 2 central spines are directed upwards and up to 3 centimeters long. The approximately 3 marginal spines are spread out and are up to 2.5 centimeters long. The flowers are 4 centimeters to 7.5 centimeters long in diameter. The pear-shaped fruits are yellowish white and tinged with purple. ==Distribution==