Cladotheria is a clade of mammals. It contains modern therian mammals and several extinct groups, such as the "dryolestoids", amphitheriids and peramurids. The clade was named in 1975 by Malcolm McKenna. In 2002, it was defined as a node-based taxon containing "the common ancestor of dryolestids and living therians, plus all its descendants". A different, stem-based definition was given in 2013, in which Cladotheria contains all taxa that are closer to Mus musculus than to the "symmetrodont" Spalacotherium tricuspidens.