Class I PI 3-kinases

Class IA PI 3-kinases are activated by receptor tyrosine kinases (RTKs). There are three catalytic subunits that are classified as class IA PI 3-kinases: • p110α • p110β • p110δ There are currently five regulatory subunits that are known to associate with class IA PI 3-kinases catalytic subunits: • p85α and p85β • p55α and p55γ • p50α ==Class IB PI 3-kinases==

Class IB PI 3-kinases are activated by G-protein-coupled receptors (GPCRs). The only known class IB PI 3-kinase catalytic subunit is p110γ. There are two known regulatory subunits for p110γ: • p101 • p84/ p87PIKAP. ==See also==