In 1981, Jones went to work in the district office of State Assemblyman
Art Agnos. In 1982, when
AIDS was still a new and largely underestimated threat, Jones co-founded the
San Francisco AIDS Foundation, then called the
Kaposi's Sarcoma Research and Education Foundation, with
Marcus Conant, Frank Jacobson, and Richard Keller. They reorganized as the San Francisco AIDS Foundation in 1984. Jones conceived the idea of the
AIDS Memorial Quilt at a candlelight memorial for Harvey Milk in 1985 and in 1987 created the first quilt panel in honor of his friend Marvin Feldman. The AIDS Memorial Quilt has grown to become the world's largest community arts project, memorializing the lives of over 85,000 Americans killed by AIDS. Jones ran for a position on the
San Francisco Board of Supervisors in the November 3, 1992 election. Jones has been working with
UNITE HERE, the hotel, restaurant, and garment workers'
labor union on homophobia issues. Another part of Jones's work with UNITE HERE is making the labor movement more open to LGBTQ members. In an interview in November 2016 with
Terry Gross on
NPR radio talk show Fresh Air, Jones described his status as
HIV-positive, and said while he first learned of his status when tests for infection came out in the 1980s, he was likely infected with the virus around the winter of 1978 or 1979, based on blood samples collected from him as part of a study he volunteered for. In the same interview, Jones also talked about the time when he became seriously ill, and how he responded rapidly to the
"cocktail" of drugs that fought the virus, in the earliest trials of it. He described his present health as good. A theme of the interview was that activism saved his life, as he was in the early drug trials, part of the group pushing the FDA (US
Food and Drug Administration) to stop doing double-blind trials as soon as it was clear that the cocktail of drugs saved lives. ==Film, theater and major parades==