Box played professional football at the
end and
halfback positions in the
National Football League (NFL) for five seasons with the
Detroit Lions from 1949 to 1950 and 1952 to 1954. In 1950, Box's second year in the NFL, Detroit's coaches sought to take advantage of Box's speed and converted him into an end. His 302 receiving yards against the Colts was the second highest in NFL history at the time and currently ranks fifth in league history. After the 1950 season, Box was selected by the
Associated Press (AP) as a second-team end on its All-Pro team. In February 1951, with the
Korean War ongoing, Box was recalled from inactive reserve status by the
United States Marine Corps. He missed the entire 1951 season due to military service. In June 1952, after being discharged from the Marine Corps, Box returned to the Lions. Box was the leading receiver on the 1952 Lions team that won the NFL championship, recording 15 touchdowns on 42 receptions for 924 yards. Box scored three touchdowns in three different games that season; no Lions player would do so again until 2025. On October 19, 1952, he led a comeback victory over the
Los Angeles Rams, with touchdown catches covering 64 and 10 yards. He led the NFL with 15 receiving touchdowns, ranked second in the league with 90 points scored, and again ranked among the league leaders with 924 receiving yards (fourth), 22.0 yards per reception (fourth), and 924 yards from scrimmage (sixth). In the
1952 NFL Championship Game, a 17–7 victory over the
Cleveland Browns, Box was used mainly as a decoy but was credited with a key block on
Doak Walker's 67-yard touchdown run. After the 1952 season, Box was selected by the AP as a first-team All Pro player and was selected to play in the
1953 Pro Bowl. In the
1953 NFL Championship Game, he had four receptions for 54 yards. In 1954, Box's final year in the NFL, he appeared in 11 games but caught only six passes for 53 yards. Over the course of his five years with the Lions, Box totaled 129 receptions for 2,665 yards and 32 touchdowns. ==Business career and later life==