Coilin protein is one of the main molecular components of Cajal bodies. Cajal bodies are non-membrane bound
nuclear bodies of varying number and composition that are involved in the
post-transcriptional modification of small nuclear and
small nucleolar RNAs. In addition to its structural role, coilin acts as glue to connect the CB to the
nucleolus. The
N-terminus of the coilin protein directs its self-oligomerization while the
C-terminus influences the number of nuclear bodies assembled per cell. Differential
methylation and
phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has
pseudogenes on chromosome 4 and chromosome 14.
nucleolar phosphoprotein p130,
SMN, and
SNRPB. ==References==