The College of Guadalupe de Zacatecas was a Roman Catholic Franciscan missionary college, or seminary, founded in Guadalupe, Zacatecas (Mexico) by the Order of Friars Minor between 1703 and 1707. The institution was established to provide specific training for priests who were to work among the indigenous populations in the Spanish colonial Viceroyalty of New Spain, present day Mexico and the southwestern United States.