The Buffaloes fielded their first lacrosse team in 2014. In their first season they finished with a winning record of 11–8. In 2017, just the program's fourth season of existence, they started the year 9–0 with highlighted wins over #9
Northwestern, #16
UMass, #14
Denver, and #6
Penn State. The 2017 team would go on to make the
2017 NCAA Division I women's lacrosse tournament, where they would lose in a rematch to UMass. They continued this success by appearing in the NCAA tournament in both
2018 and
2019. In 2026, Colorado won its first Big 12 tournament championship, defeating Florida 8–6 in the final. As of 2023, Colorado has an all time record of 109–60. ==Individual career records==