In 1997, Sison was a walk-in applicant in
RPN 9 for a position of a news anchor. Her first job was being a news anchor for the network's 5PM newscast substitute anchor for Cielo Villaluna's co-anchor who was on leave that time. Her appearance at RPN 9 caught the attention of
ABS-CBN where she also applied and subsequently joined
Studio 23, ABS-CBN's sister network owned by
ABS-CBN Corporation, as a features reporter and SNN (later rebranded as
ANC). ABS-CBN promoted her after 8 months and she became a reporter for hard news in
TV Patrol. as one of the show's hosts. Sison also hosted a
reality television program called
Kakasa Ka Ba? that she co-hosted with JV Villar. In 2006, she exited ABS-CBN through a retirement package. In 2007, 10 years of her career, as soon as her non-compete clause contract ended in ABS-CBN, Sison continued her career in GMA Network.
News on Q,
On Call: Siksik Sa Impormasyon. Bilis na Pag-Aksyon, and
Balitanghali (a late morning newscast on GMA News TV and GTV which she co-hosted with
Raffy Tima). In GMA's main channel, she is one of the hosts of the morning program
Unang Hirit. She also hosts the medical-focused show
Pinoy M.D., which got a radio version in DZBB (GMA's flagship radio station) and officially titled as
Pinoy M.D. sa Dobol B. In 2018, she is the very first recipient of the Bantog award for Media Practitioner in Television given by
Department of Science and Technology as a result of her hosting of
Pinoy M.D. She was also rewarded with a
P 100,000 cash, which she opted to give to the
Kapuso Foundation as a donation. Despite the situation, Sison remained calm and some
netizens condemned Gordon's actions as being rude and lauded Sison's composure. In 2023, she announced she will retire hosting
Unang Hirit after 13 years to focus on her family and health, while she retains anchoring
Balitanghali, and as a host of
Pinoy MD and two of DZBB shows (
Pinoy MD sa Super Radyo DZBB, and as a co-host of
Arnold Clavio on
One on One: Walang Personalan). == Personal life ==