The Captain Cook Highway commences at the northern end of the
Bruce Highway (Mulgrave Road), in the Cairns CBD. It runs through the CBD and the suburbs of Cairns North and Aeroglen as Sheridan Street, with a speed limit of 60km/h. In this section, it intersects with Airport Drive, providing a connection to Cairns Airport. After the intersection with Aeroglen Drive, the northerly and southerly directions of the highway become separated by a median and the speed limit increases to 80km/h. It runs as
National Route 1 north past the suburbs of Machans Beach, Holloways Beach, and Yorkeys Knob, until it reaches the intersection of the Cairns Western Arterial Road towards the Redlynch Valley. As of 25 November 2021, the highway branches off from this intersection onto the Smithfield Bypass (now renamed Kudakai Crossland Connection); a
two-lane highway which follows a path to the east of the Smithfield business centre. This was constructed at a cost of $164 million. The original route continues north to the intersection of the Kennedy Highway in Smithfield, next to the Smithfield Shopping Centre. From this intersection, the highway continues north to the intersection of McGregor road, next to James Cook University, where it joins with the Smithfield Bypass. The two routes recombine and continue north as State Route 44 past the suburbs of Trinity Park, Trinity Beach, Kewarra Beach, Clifton Beach, Palm Cove, and Ellis Beach. It then continues along the coast through Wangetti, Craiglie and Killaloe, then west between Bonnie Doon in the north and Cassowary and Shannonvale in the south, where it passes the exit to Mossman-Mount Molloy Road (State Route 44) to the south, before turning north-west to its terminus in Mossman. ==History==