At the end of the 1960s and beginning of the 1970s, the first regional tournaments began to emerge in Brazilian football. However, it was in 1999 that the Copa Centro-Oeste came into being. Teams from the central-west region of Brazil participated, along with teams from
Espírito Santo, from the southeast region, and
Tocantins, in the northern region.
Minas Gerais state clubs only competed in the first Copa Centro-Oeste edition, in 1999, joining the new
Copa Sul-Minas in 2000. In 1999, the winner of the Copa Centro-Oeste qualified for the
Copa CONMEBOL. From 2000 to 2002, the champion went on to compete in the
Copa dos Campeões. Following changes to the Brazilian football calendar, the tournament was discontinued in 2003. However, in October 2025, the CBF announced the return of the competition after 24 years. ==Format==